Abstract
Polymersome-based nanomotors represent a cutting-edge development in nanomedicine, merging the unique vesicular properties of polymersomes with the active propulsion capabilities of synthetic nanomotors. As a vesicular structure enclosed by a bilayer membrane, polymersomes can encapsulate both hydrophilic and hydrophobic cargoes. In addition, their physical-chemical properties such as size, morphology, and surface chemistry are highly tunable, which makes them ideal for various biomedical applications. The integration of motility into polymersomes enables them to actively navigate biological environments and overcome physiological barriers, offering significant advantages over passive delivery platforms. Recent breakthroughs in fabrication techniques and motion control strategies, including chemically, enzymatically, and externally driven propulsion, have expanded their potential for drug delivery, biosensing, and therapeutic interventions. Despite these advancements, key challenges remain in optimizing propulsion efficiency, biocompatibility, and in vivo stability to translate these systems into clinical applications. In this perspective, we discuss recent advancements in the preparation and motion control strategies of polymersome-based nanomotors, as well as their biomedical-related applications. The molecular design, fabrication approaches, and nanomedicine-related utilities of polymersome-based nanomotors are highlighted, to envisage the future research directions and further development of these systems into effective, precise, and smart nanomedicines capable of addressing critical biomedical challenges.