Characterization of a myc-containing retrovirus generated by propagation of an MH2 viral subgenomic RNA

通过MH2病毒亚基因组RNA的扩增产生的含myc基因的逆转录病毒的特性分析

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Abstract

We have previously isolated, from wild-type MH2 virus that contains the two oncogenes mil and myc, mutants defective in one or the other oncogene product. We report here the molecular cloning and extensive characterization of MH2 CL25 provirus lacking the v-mil oncogene. Our results indicate that this virus corresponds to the propagation of the 2.8-kilobase subgenomic RNA of MH21.

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