Abstract
Sustainable food production systems can be achieved through a circular economy, yet the whole system remains susceptible to various known, emerging, or even unknown/novel food safety hazards and contaminants. These upcycled foods can introduce related risks for human or animal health and ecological balance. These potential risks can be effectively mitigated by adopting integrated smart "safe-by-design" approaches. These multi-effective strategies can cascade far beyond consequences by addressing all potential food safety risks at each stage of the food supply chain, even at the post-consumption stage. Sustainability through circularity without harming food production systems can be achieved by integrating and harmonizing evidence-based risk control strategies, fostered with extensive and objective-oriented research and development, and preemptive ideological relationships with relevant stakeholders. The current review aimed at addressing the possible occurrence and risks associated with potential emerging or unknown hazards/contaminants linked to various production systems, along with relevant mitigation strategies. It also highlights the importance of implementing quality control measures and safety precautions throughout the food supply chain to prevent the occurrence and propagation of hazardous substances. Agricultural production systems can be transformed into sustainable entities by vigilant monitoring of end-product quality through the use of upcycled technologies.