gem-Difluorination of carbon-carbon triple bonds using Brønsted acid/Bu(4)NBF(4) or electrogenerated acid

使用布朗斯台德酸/Bu₄NBF₄或电生成的酸对碳碳三键进行双氟化反应

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Abstract

gem-Difluorination of carbon-carbon triple bonds was conducted using Brønsted acids, such as Tf(2)NH and TfOH, combined with Bu(4)NBF(4) as the fluorine source. The electrochemical oxidation of a Bu(4)NBF(4)/CH(2)Cl(2) solution containing alkyne substrates could also give the corresponding gem-difluorinated compounds (in-cell method). The ex-cell electrolysis method was also applicable for gem-difluorination of alkynes.

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