Abstract
The design of environmentally friendly methods for synthesizing molecular receptors is an expanding area within applied organic chemistry. This work systematically summarizes advances in the mechanochemical synthesis of molecular chemoreceptors. It discusses key achievements related to the synthesis of chemoreceptors containing azine, Schiff base, thiosemicarbazone, hydrazone, rhodamine 6G, imide, or amide moieties. Additionally, it highlights the application potential of mechanochemically synthesized molecular chemoreceptors in the recognition of ions and small molecules, along with a discussion of the mechanisms of detection processes.