Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts

小鼠输卵管高级别浆液性癌反映了人类相应癌的基因组改变、基因表达谱和免疫微环境

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作者:Kevin W McCool #, Zachary T Freeman #, Yali Zhai #, Rong Wu, Kevin Hu, Chia-Jen Liu, Scott A Tomlins, Eric R Fearon, Brian Magnuson, Rork Kuick, Kathleen R Cho

Significance

The acquired gene mutations, broad genomic alterations, and gene expression and immune cell-tumor axis changes in a mouse model of oviductal serous carcinoma closely mirror those of human tubo-ovarian high-grade serous carcinoma.

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