Abstract
BACKGROUND: Electrical impedance tomography is a continuous imaging method capable of measuring lung volume changes. The purpose of this study was to examine whether EIT was capable of evaluating the degree of obstructive ventilatory defect (OVD) on the global and regional level. METHODS: 41 healthy subjects with no lung diseases and 67 subjects suffering from obstructive lung diseases were examined using EIT and spirometry during forced vital capacity (FVC) maneuver. The subjects were divided into control group (n = 41), early airway obstruction group (n = 26), mild group (n = 17), moderate group (n = 16) and severe group (n = 8) according to the degree of obstruction. Forced expiratory volume in 1 second (FEV1) and FEV1/FVC were determined by EIT. The mode index (MI) was proposed to evaluate the degree of global and regional obstruction; the effectiveness of MI was validated by evaluating posture related change of lung emptying capacity in sitting and supine postures; the degree of regional obstruction was determined according to the cut-off values of MI obtained from receiver operating characteristic (ROC) analysis; regional obstruction was located in the four-quadrant region of interest (ROI) and the contour-map ROI with contour lines at the cut-off values of MI. RESULTS: Significant differences were found between different groups (P<0.05) and the global MI was 0.93±0.03, 0.86±0.05, 0.81±0.09, 0.73±0.09 and 0.60±0.11 (mean ±SD), respectively. The cut-off MI value was 0.90, 0.83, 0.77, and 0.65, respectively. CONCLUSION: The results indicated the potential of EIT to evaluate the degree of obstruction in patients with obstructive ventilatory defect on the global and regional level.