Abstract
Calculating risk from seafood exposure to persistent organic pollutants continues to be problematic as estimates of exposure from diet require extensive monitoring of fish species and limited assessments of bioavailability from sediments where the contaminants tend to reside. Previous studies in our laboratory utilized a laboratory-based isotope dilution method (IDM) to estimate the bioavailability of DDT [1,1,1-trichloro-2, 2-bis(p-chloro-phenyl)ethane] and its metabolites from sediment to biota from a superfund site on the shelf of the Palos Verdes (PVS) Peninsula in California (USA). Using a biota-sediment accumulation factor (BSAF) derived from IDM and biomagnification factors (BMF) calculated from previous studies as well as seafood-consumption data specific to anglers in the PVS area, we estimated cancer and non-cancer risks for anglers and nursing infants representing sensitive groups. Predicted cancer risks from consumption of White croaker (Genyonemus lineatus) to the 50th and 95th percentile to all shore mode anglers were, respectively, 2×10(-7) and 7×10(-7), which were similar to field studies using fish concentrations of all DDT isomers and their environmental degradates (ΣDDT) from collected animals. The calculated non-cancer hazard quotient values for the 50th and 95th percentile shore mode anglers consuming White croaker from this study (0.008 and 0.023, respectively) were also of similar magnitude as those obtained from studies based on samples obtained solely from fish. For nursing infants, similar results were also observed. These results indicate that estimates of bioavailability using IDM from sediment could be used accurately to determine risk to ΣDDT in humans from fish consumption.