Abstract
Leukemia (blood cancer) diseases arise when the number of White blood cells (WBCs) is imbalanced in the human body. When the bone marrow produces many immature WBCs that kill healthy cells, acute lymphocytic leukemia (ALL) impacts people of all ages. Thus, timely predicting this disease can increase the chance of survival, and the patient can get his therapy early. Manual prediction is very expensive and time-consuming. Therefore, automated prediction techniques are essential. In this research, we propose an ensemble automated prediction approach that uses four machine learning algorithms K-Nearest Neighbor (KNN), Support Vector Machine (SVM), Random Forest (RF), and Naive Bayes (NB). The C-NMC leukemia dataset is used from the Kaggle repository to predict leukemia. Dataset is divided into two classes cancer and healthy cells. We perform data preprocessing steps, such as the first images being cropped using minimum and maximum points. Feature extraction is performed to extract the feature using pre-trained Convolutional Neural Network-based Deep Neural Network (DNN) architectures (VGG19, ResNet50, or ResNet101). Data scaling is performed by using the MinMaxScaler normalization technique. Analysis of Variance (ANOVA), Recursive Feature Elimination (RFE), and Random Forest (RF) as feature Selection techniques. Classification machine learning algorithms and ensemble voting are applied to selected features. Results reveal that SVM with 90.0% accuracy outperforms compared to other algorithms.