Screening of ligands for redox-active europium using magnetic resonance imaging

使用磁共振成像筛选具有氧化还原活性的铕配体

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作者:Brooke A Corbin, Lina A Basal, Susan A White, Yimin Shen, E Mark Haacke, Kenneth W Fishbein, Matthew J Allen

Abstract

We report a screening procedure to predict ligand coordination to EuII and EuIII using magnetic resonance imaging in which bright images indicate complexation and dark images indicate no complexation. Here, paramagnetic GdIII is used as a surrogate for EuIII in the screening procedure to enable detection with magnetic resonance imaging. The screening procedure was tested using a set of eight ligands with known coordination to EuII and EuIII, and results were found to be consistent with expected binding. Validation of the screening procedure with known coordination chemistry enables use with new ligands in the future.

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