Abstract
Heavy metals (HMs) are among the most important toxic agents since they reach the soil through various routes and accumulate in the food chain. Therefore, HMs induce problems in soil integrity and in plant, animal, and human health. Alfalfa (Medicago sativa L.) is a significant crop worldwide, utilized in animal production. Furthermore, because of its nitrogen-absorbing ability via symbiotic strains of bacteria, it increases soil productivity. However, there are relatively few studies investigating the effects of HMs and their alleviation possibilities on alfalfa plants. Therefore, the goal of this review is to clarify the current state of research into HM-induced alterations in alfalfa and to determine the extent to which externally applied microorganisms and chemical compounds can mitigate the negative effects. The aim is to indicate areas of development towards further understanding of HM detoxification in alfalfa and to identify future research directions.