An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

整合了响应 Myc 致癌转录因子的基因数据库:直接基因组靶点的鉴定

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Abstract

We report a database of genes responsive to the Myc oncogenic transcription factor. The database Myc Target Gene prioritizes candidate target genes according to experimental evidence and clusters responsive genes into functional groups. We coupled the prioritization of target genes with phylogenetic sequence comparisons to predict c-Myc target binding sites, which are in turn validated by chromatin immunoprecipitation assays. This database is essential for the understanding of the genetic regulatory networks underlying the genesis of cancers.

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