Tunable Thermal-Sensitive Polymer-Graphene Oxide Composite for Efficient Capture and Release of Viable Circulating Tumor Cells

可调热敏聚合物-氧化石墨烯复合材料可有效捕获和释放活循环肿瘤细胞

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作者:Hyeun Joong Yoon, Apoorv Shanker, Yang Wang, Molly Kozminsky, Qu Jin, Nallasivam Palanisamy, Monika L Burness, Ebrahim Azizi, Diane M Simeone, Max S Wicha, Jinsang Kim, Sunitha Nagrath

Abstract

A highly sensitive microfluidic system to capture circulating tumor cells from whole blood of cancer patients is presented. The device incorporates graphene oxide into a thermoresponsive polymer film to serve as the first step of an antibody functionalization chemistry. By decreasing the temperature, captured cells may be released for subsequent analysis.

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