Abstract
A highly efficient method for controllable double CF(2)-insertion into pentafluorophenylcopper species using TMSCF(3) as difluoromethylene source has been developed. The newly generated fluoroalkylcopper(i) species, C(6)F(5)CF(2)CF(2)Cu, shows good reactivity towards a myriad of structurally diverse aryl, heteroaryl and alkenyl iodides. This protocol is easy to handle, ready to scale up and applicable for the synthesis of relative complex molecules, thus providing a convenient method for facile access to tetrafluoroethylene-bridged structures.