Abstract
Background/Objectives: Quantitative sensory testing (QST) is one of the most reliable methods for assessing Fibromyalgia Syndrome (FMS). Despite its importance, there are still controversies regarding the correct interpretation of evoked responses, as they may vary depending on the protocol, individual characteristics, disease severity, and other factors. This study aims to examine how QST has been applied as an outcome measure in FMS. Methods: We considered three databases (Medline, Embase, and Web of Science) until June 2024. From a total of 2512 studies, 126 (39 RCTs and 87 non-RCTs) were selected for full reading after assessment for risk of bias and eligibility criteria. These criteria included at least one type of QST and a clear diagnosis of fibromyalgia (FMS). Results: The results highlighted a lack of standardization in QST, as no reported protocols were followed and there was no specific number of tender points tested for FMS. Additionally, there was inconsistency in the selection of sites and types of tests conducted. Conclusions: This heterogeneity in methodology may affect the comparability and interpretation of results, underscoring the urgent need for standardized guidelines for conducting QST in fibromyalgia studies. A clear understanding of how QST has been measured could prompt a reevaluation of current approaches to FMS assessment, leading to more accurate interpretations and, ultimately, improved management of this complex condition.