Abstract
Cerium oxide nanoparticles (CeO(2)-NPs) have garnered significant interest due to their unique properties as well as a wide range of applications in the environmental and biomedical fields. This work examines the recent advances in the production of CeO(2)-NPs using various biological agents, including plant extracts and biosources, as sustainable and eco-friendly alternatives to conventional synthetic routes. The formation mechanisms, structural characteristics, and influence of factors on the synthesis of CeO(2)-NPs were discussed. We found that most CeO(2)-NPs possessed spherical shapes, small particle sizes (10-100 nm), and large surface areas (12-100 m(2) g(-1)). Bio-mediated CeO(2)-NPs and their composites had diverse biomedical applications such as antibacterial, antifungal, antioxidant, anticancer, neuroprotective, enzymatic, biosensing, and seed germination activities. Furthermore, CeO(2)-based composites, such as ZnO-CeO(2), Ag-doped CeO(2), cellulose/CeO(2), CeO(2)/biochar, and Cu/CeO(2), acted as photocatalysts and adsorbents for wastewater treatment applications. The performance of CeO(2) and its composites in the removal of organic pollutants such as dyes, antibiotics, nonsteroidal anti-inflammatory drugs, pesticides, and other organic compounds was evaluated. Remarkably, CeO(2)-NPs and their composites exhibited good adsorption capacities of 46-201 mg g(-1) and removal efficiency of up to 99% against heavy metals, dyes, antibiotics, and inorganic contaminants. Finally, this review analyzed the limitations and proposed future research directions for biosynthesized CeO(2)-NPs and their composites in biomedical and environmental technologies.