A case of non-paraneoplastic anti-N-methyl d-aspartate receptor encephalitis presenting as a neuropsychiatric disorder

一例非副肿瘤性抗N-甲基-D-天冬氨酸受体脑炎,表现为神经精神障碍

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Abstract

N-methyl d-aspartate receptor antibody encephalitis can often be a paraneoplastic manifestation of occult malignancy such as ovarian teratoma and rarely teratoma of mediastinum or testis and small cell lung carcinoma. We report a case of non-paraneoplastic anti-N-methyl d-aspartate receptor antibody-positive autoimmune encephalitis in a young patient who presented with neuropsychiatric features and made a very good recovery following treatment with intravenous immunoglobulin and steroids. The case highlights the need for increased vigilance for the condition in young females with or without a previous psychiatric history and emphasises the need for a multidisciplinary approach in the management of this challenging disorder with a good prognosis.

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