Zinc Iodide Dimethyl Sulfoxide Reduces Collagen Deposition by Increased Matrix Metalloproteinase-2 Expression and Activity in Lung Fibroblasts

碘化锌二甲基亚砜通过增加肺成纤维细胞中的基质金属蛋白酶-2 表达和活性来减少胶原沉积

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作者:Michael Roth, Bo Han, Chong Teck S'ng, Ba Xuan Hoang, Christopher Lambers

Conclusion

The data suggest that the combination of ZnI with DMSO reduces fibrotic processes by increasing the degradation of collagen type I by up-regulating the activity of gelatinases. Thus, the combination of ZnI with DMSO might be considered for treatment of fibrotic disorders of the lung. DMSO supported the beneficial effects of ZnI.

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