Reduced BNT162b2 Messenger RNA Vaccine Response in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Naive Nursing Home Residents

严重急性呼吸综合征冠状病毒2 (SARS-CoV-2) 初治养老院居民对BNT162b2信使RNA疫苗的反应降低

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作者：Canaday,David H,Carias,Lenore,Oyebanji,Oladayo A,Keresztesy,Debbie,Wilk,Dennis,Payne,Michael,Aung,Htin,St Denis,Kerri,Lam,Evan C,Rowley,Christopher F,Berry,Sarah D,Cameron,Cheryl M,Cameron,Mark J,Wilson,Brigid,Balazs,Alejandro B,Gravenstein,Stefan,King,Christopher L
期刊：Clinical Infectious Diseases影响因子：7.300
时间：2021起止号：2021 Dec 6;73(11):2112-2115
doi：10.1093/cid/ciab447

Abstract

After BNT162b2 messenger RNA vaccination, antibody levels to spike, receptor-binding domain, and virus neutralization were examined in 149 nursing home residents and 110 healthcare worker controls. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-naive nursing home residents' median post-second vaccine dose antibody neutralization titers are one-quarter that of SARS-CoV-2-naive healthcare workers.

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