snRNA-seq of human cutaneous neurofibromas before and after selumetinib treatment implicates role of altered Schwann cell states, inter-cellular signaling, and extracellular matrix in treatment response

ClinicalTrials.gov NCT02839720. Keywords: Cell-to-cell-communication; CellChat; Cutaneous neurofibroma; Differential gene expression; Ingenuity pathway analysis; Neurofibromatosis; RNA velocity; Scriabin; Selumetinib; Single nuclei sequencing; Tumor microenvironment.