Abstract
Integrating machine learning (ML) with nanophotonic engineering, this work achieves unprecedented performance in surface plasmon resonance (SPR) biosensing through a co-designed gold-coated photonic crystal fiber (PCF-SPR) sensor and multi-algorithm computational framework. An asymmetric circular PCF structure with concentric air-hole rings ([Formula: see text], [Formula: see text]) and a 50 nm gold layer maximizes evanescent field-analyte overlap, generating complex spectral signatures ideal for machine learning interpretation. High-fidelity COMSOL Multiphysics simulations produce 1560 synthetic data points across refractive indices (RIs) of 1.33-1.38, capturing confinement loss, wavelength sensitivity, and effective permittivity. Three regression models-Multiple Linear Regression (MLR), Support Vector Regression (SVR), and Random Forest Regression (RFR)-are rigorously evaluated for predicting optical responses. The sensor demonstrates a record wavelength sensitivity of 31 846.46 nm/RIU-1 at [Formula: see text], with minimal variation (0.02%) across the biological range, alongside a resolution of [Formula: see text] RIU. Crucially, MLR outperforms nonlinear counterparts, achieving superior accuracy in confinement loss (MAE = 3.97, RMSE = 5.03) and sensitivity prediction (MAE = 40.18, RMSE = 50.54). This synergy of optimized pure-gold microstructures and interpretable machine learning establishes a robust pipeline for high-sensitivity, noise-resilient biosensing, surpassing prior ML-enhanced plasmonic sensors in critical performance metrics while simplifying fabrication.