Abstract
PURPOSE: To evaluate the effect of autologous platelet-rich plasma (PRP) eye drops on optical quality and visual acuity in eyes implanted with a trifocal diffractive intraocular lens (IOL). METHODS: In this retrospective cohort study of 128 eyes from 128 patients undergoing femtosecond laser-assisted cataract surgery with implantation of the CNWT Clareon PanOptix (Alcon Inc.) IOL, patients were assigned to one of two groups: the PRP group (n = 62), which received postoperative PRP eye drops, and the conventional treatment group (n = 66). At 3 weeks postoperatively, optical parameters-including the objective scatter index (OSI), modulation transfer function (MTF) cutoff, and Strehl ratio (SR)-were measured with a double-pass system. Uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA) at 4 m, as well as uncorrected near visual acuity (UNVA) at 40 cm, were recorded in logMAR units. RESULTS: The PRP group demonstrated superior optical quality across all measured parameters compared to the control group, with lower OSI (1.60 vs. 3.14), higher MTF cutoff (31.93 vs. 19.90 cycles/degree), and higher SR (0.15 vs. 0.12) (all P < 0.001). Visual acuity was also significantly better in the PRP group, with lower mean logMAR UDVA (0.05 vs. 0.10; P < 0.001), CDVA (0.01 vs. 0.05; P < 0.001), and UNVA (0.13 vs. 0.18; P = 0.007). Multivariate analyses confirmed that the use of PRP eye drops was independently associated with improvements in all three optical parameters: OSI (B = -1.488), MTF cutoff (B = 12.038), and SR (B = 0.039) (all P < 0.001). CONCLUSIONS: The use of autologous PRP eye drops improves optical quality and visual acuity at all distances following trifocal diffractive IOL implantation. PRP eye drops may serve as a beneficial adjunct for postoperative management in patients undergoing this procedure.