Abstract
Biomedical data visualization is critical for interpreting complex datasets, yet the clarity and quality of visualizations vary widely across tools and applications. This study introduces a comprehensive framework for evaluating biomedical figures and benchmarking visualization platforms. We developed Metrics for Evaluation and Discretization of Biomedical Visuals using an Iterative Scoring algorithm (M.E.D.V.I.S.), a quantification system that systematically assesses figure quality based on four criteria: Complexity, color usage, whitespace, and the number of distinct visualizations. The algorithm integrates dimensionality reduction, clustering, and thresholding to classify figures and generate tailored feedback for improvement. In parallel, we conducted a comparative analysis of 26 widely used visualization tools, evaluating each based on ease of use, customizability, financial cost, and required background knowledge. To demonstrate real-world applicability, we present case studies on figure evaluation in published research and introduce SpatioView, an interactive, browser-based platform for exploring spatial omics data. Collectively, our findings highlight the need for standardized evaluation methods and provide accessible solutions for improving figure design in biomedical research, education, and industry.