Abstract
Predictive brain theory challenges the general assumption of a brain extracting knowledge from sensations and considers the brain as an organ of inference, actively constructing explanations about reality beyond its sensory evidence. Predictive brain has been formalized through Bayesian updating, where top-down predictions are compared with bottom-up evidence. In this article, we propose a different approach to predictive brain based on quantum probability-we call it Quantum Predictive Brain (QPB). QPB is consistent with the Bayesian framework, but considers it as a special case. The tenet of QPB is that top-down predictions and bottom-up evidence are complementary, as they cannot be co-jointly determined to pursue a univocal model of brain functioning. QPB can account for several high-order cognitive phenomena (which are problematic in current predictive brain theories) and offers new insights into the mechanisms of neural reuse.