Abstract
Orthopaedic biomechanics and bioengineering is a founding discipline of biomedical engineering that focuses on the effects of mechanical stress and strain on musculoskeletal tissues during growth, function and repair. In the past decade the gut microbiome has emerged as a contributor to disease processes throughout the body, but only recently has been shown to influence orthopaedic biomechanics. Here I review emergent findings showing that the gut microbiome can regulate important aspects of the musculoskeletal system including growth and development; tissue failure and disease; and orthopaedic surgery. These early findings suggest that the microbiome may help answer questions in orthopaedic biomechanics that are not well addressed by current interventions, and highlights the promise of the emerging field of "Musculoskeletal Microbiology".