Manipulation of host membranes by the bacterial pathogens Listeria, Francisella, Shigella and Yersinia

细菌病原体李斯特菌、弗朗西斯菌、志贺氏菌和耶尔森氏菌对宿主细胞膜的操纵

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Abstract

Bacterial pathogens display an impressive arsenal of molecular mechanisms that allow survival in diverse host niches. Subversion of plasma membrane and cytoskeletal functions are common themes associated to infection by both extracellular and intracellular pathogens. Moreover, intracellular pathogens modify the structure/stability of their membrane-bound compartments and escape degradation from phagocytic or autophagic pathways. Here, we review the manipulation of host membranes by Listeria monocytogenes, Francisella tularensis, Shigella flexneri and Yersinia spp. These four bacterial model pathogens exemplify generalized strategies as well as specific features observed during bacterial infection processes.

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