Abstract
Emerging infectious diseases pose a significant threat to global public health and economic security, with zoonoses accounting for a substantial proportion. Livestock such as cattle and sheep are critical reservoirs for zoonotic pathogens and play a key role in transmitting these pathogens to humans and other animals, including dogs and wildlife, due to their close interaction with diverse populations. In this study, we introduce Zoonosis (http://zoonosis.cn/zoonosis/), a comprehensive database that integrates data on pathogens, including Brucella, Mycobacterium tuberculosis, and Bacillus anthracis. Currently, Zoonosis integrates over 4500 samples from more than 60 countries, with a total data volume of 1.8TB, providing a global perspective on zoonotic disease distribution. Equipped with user-friendly visualization and analysis tools, Zoonosis enables rapid biological data interpretation, aiding disease diagnosis and prevention. This resource supports virology, zoology, and epidemiology experts in monitoring cross-species transmissions and mitigating future zoonotic outbreaks. Database URL: http://zoonosis.cn/zoonosis/.