Abstract
BACKGROUND AND PURPOSE: Deep-learning (DL) models for segmentation of the gross tumor volume (GTV) in radiotherapy are generally based on clinical delineations which suffer from inter-observer variability. The aim of this study was to compare performance of a DL-model based on clinical glioblastoma GTVs to a model based on a single-observer edited version of the same GTVs. MATERIALS AND METHODS: The dataset included imaging data (Computed Tomography (CT), T1, contrast-T1 (T1C), and fluid-attenuated-inversion-recovery (FLAIR)) of 259 glioblastoma patients treated with post-operative radiotherapy between 2012 and 2019 at a single institute. The clinical GTVs were edited using all imaging data. The dataset was split into 207 cases for training/validation and 52 for testing.GTV segmentation models (nnUNet) were trained on clinical and edited GTVs separately and compared using Surface Dice with 1 mm tolerance (sDSC(1mm)). We also evaluated model performance with respect to extent of resection (EOR), and different imaging combinations (T1C/T1/FLAIR/CT, T1C/FLAIR/CT, T1C/FLAIR, T1C/CT, T1C/T1, T1C). A Wilcoxon test was used for significance testing. RESULTS: The median (range) sDSC(1mm) of the clinical-GTV-model and edited-GTV-model both evaluated with the edited contours, was 0.76 (0.43-0.94) vs. 0.92 (0.60-0.98) respectively (p < 0.001). sDSC(1mm) was not significantly different between patients with a biopsy, partial, and complete resection. T1C as single input performed as good as use of imaging combinations. CONCLUSIONS: High segmentation accuracy was obtained by the DL-models. Editing of the clinical GTVs significantly increased DL performance with a relevant effect size. DL performance was robust for EOR and highly accurate using only T1C.