Abstract
Plants belonging to the Ilex species are distinguished by their rich composition of diverse phenolic compounds and various bioactive substances, which demonstrate dual functionalities in therapeutic applications and health promotion. In recent years, these plants have garnered significant interest among researchers. While the application scope of plant polyphenols (PPs) is extensive, the exploration and utilization of holly polyphenols (HPs) remain comparatively underexplored. This article reviews the research advancements regarding the predominant phenolic compounds present in commonly studied Ilex species over the past five years and summarizes the application studies of PPs across various domains, including pharmacological applications, food technology, health supplements, and cosmetic formulations. The objective of this review is to provide insights into the systematic research and development of HPs, offering references and recommendations to enhance their value.