Abstract
BACKGROUND: Spectral imaging of photon-counting detector CT (PCD-CT) scanners allows for generating virtual non-contrast (VNC) reconstruction. By analyzing 12 abdominal organs, we aimed to test the reliability of VNC reconstructions in preserving HU values compared to real unenhanced CT images. METHODS: Our study included 34 patients with pancreatic cystic neoplasm (PCN). The VNC reconstructions were generated from unenhanced, arterial, portal, and venous phase PCD-CT scans using the Liver-VNC algorithm. The observed 11 abdominal organs were segmented by the TotalSegmentator algorithm, the PCNs were segmented manually. Average densities were extracted from unenhanced scans (HU(unenhanced)), postcontrast (HU(postcontrast)) scans, and VNC reconstructions (HU(VNC)). The error was calculated as HU(error)=HU(VNC)-HU(unenhanced). Pearson's or Spearman's correlation was used to assess the association. Reproducibility was evaluated by intraclass correlation coefficients (ICC). RESULTS: Significant differences between HU(unenhanced) and HU(VNC[unenhanced]) were found in vertebrae, paraspinal muscles, liver, and spleen. HU(VNC[unenhanced]) showed a strong correlation with HU(unenhanced) in all organs except spleen (r = 0.45) and kidneys (r = 0.78 and 0.73). In all postcontrast phases, the HU(VNC) had strong correlations with HU(unenhanced) in all organs except the spleen and kidneys. The HU(error) had significant correlations with HU(unenhanced) in the muscles and vertebrae; and with HU(postcontrast) in the spleen, vertebrae, and paraspinal muscles in all postcontrast phases. All organs had at least one postcontrast VNC reconstruction that showed good-to-excellent agreement with HU(unenhanced) during ICC analysis except the vertebrae (ICC: 0.17), paraspinal muscles (ICC: 0.64-0.79), spleen (ICC: 0.21-0.47), and kidneys (ICC: 0.10-0.31). CONCLUSIONS: VNC reconstructions are reliable in at least one postcontrast phase for most organs, but further improvement is needed before VNC can be utilized to examine the spleen, kidneys, and vertebrae.