Abstract
BACKGROUND: Smoking is one of the most significant environmental risk factors for Rheumatoid Arthritis (RA). However, there is a lack of research examining the impact of smoking trends on the RA disease burden globally. METHODS: This study utilized the Global Burden of Disease (GBD) 2021 database to analyze the burden of RA attributable to smoking. Five key indicators were examined: Deaths, Disability-Adjusted Life Years (DALYs), Years Lived with Disability (YLDs), Years of Life Lost (YLLs), and the Socio-Demographic Index (SDI). The analysis was stratified by age, sex, year, and region. Additionally, smoking prevalence and tobacco use data from 2000 to 2021 were extracted from the World Health Organization (WHO) to evaluate trends in smoking and RA burden. RESULTS: From 1990 to 2021, while the age-standardized Smoking Attributable Fraction for RA burden metrics generally declined globally, alongside decreasing age-standardized rates (ASR) of smoking-attributable burden in many regions, the absolute global number of both deaths and DALYs due to smoking-attributable RA paradoxically increased (deaths: from 1,792-2,264; DALYs: from 145,727-215,780; all 95% Uncertainty Intervals provided in text). Significant disparities were observed: high-income regions demonstrated greater reductions in smoking-attributable burden than low- and middle-income regions. Males and older populations experienced higher burdens across all metrics. Moderate SDI countries had the highest smoking-attributable age-standardized Deaths and YLLs rate (e.g., Deaths 0.04 per 100,000 population), whereas high SDI countries showed higher YLDs rate (e.g., 3.5 per 100,000 population). CONCLUSIONS: This study highlights the persistent impact of smoking on the global RA burden and underscores the critical role of tobacco control policies in alleviating this burden. Tailored interventions for high-burden regions (e.g., Eastern Europe and East Asia) and high-risk populations (e.g., middle-aged and older males) are essential. Strengthening early interventions and resource allocation in low- and middle-income regions and enhancing long-term RA management in high-income regions are crucial steps to further reduce the global RA burden.