Generation of an induced pluripotent stem cell line SDUBMSi005-A from a patient with double primary gastric and colon carcinoma
从患有双原发性胃癌和结肠癌的患者体内生成诱导性多能干细胞系 SDUBMSi005-A
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作者：Yan Li, Xiaolin Liu, Dandan Chen, Yong Liu, Yanyan Ma, Qiji Liu, Wenjie Sun, Jisheng Li
| 期刊： | Stem Cell Research | 影响因子： | 0.800 |
| 时间： | 2021 | 起止号： | 2021 May:53:102253. |
| doi： | 10.1016/j.scr.2021.102253 | 研究方向： | 发育与干细胞、肿瘤 |
| 疾病类型： | 肠癌、胃癌 | 细胞类型： | 干细胞 |
Abstract
It has been reported that mutations in CDH1 gene are associated with genetic susceptibility to colon, stomach, breast and prostate cancers. Here, an induced pluripotent stem cell (iPSC) line from a patient with double primary gastric and colon carcinoma carrying germline mutation (c. 1679C > G) in CDH1 gene was generated. The iPSC line had normal karyotype, expressed pluripotent markers and had ability to generate three germ layers.
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