Abstract
Recent discoveries have revealed that, during viral infection, the presence of the RNA modification N(6)-methyladenosine (m(6)A) on viral and cellular RNAs has profound impacts on infection outcome. Although m(6)A directly regulates many viral RNA processes, its effects on cellular RNAs and pathways during infection have only recently begun to be elucidated. Disentangling the effects of m(6)A on viral and host RNAs remains a challenge for the field. m(6)A has been found to regulate host responses such as viral RNA sensing, cytokine responses, and immune cell functions. We highlight recent findings describing how m(6)A modulates host responses to viral infection and discuss future directions that will lead to a synergistic understanding of the processes by which m(6)A regulates viral infection.