REPIC: a database for exploring the N(6)-methyladenosine methylome

REPIC:一个用于探索N(6)-甲基腺苷甲基化组的数据库

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Abstract

The REPIC (RNA EPItranscriptome Collection) database records about 10 million peaks called from publicly available m(6)A-seq and MeRIP-seq data using our unified pipeline. These data were collected from 672 samples of 49 studies, covering 61 cell lines or tissues in 11 organisms. REPIC allows users to query N(6)-methyladenosine (m(6)A) modification sites by specific cell lines or tissue types. In addition, it integrates m(6)A/MeRIP-seq data with 1418 histone ChIP-seq and 118 DNase-seq data tracks from the ENCODE project in a modern genome browser to present a comprehensive atlas of m(6)A methylation sites, histone modification sites, and chromatin accessibility regions. REPIC is accessible at https://repicmod.uchicago.edu/repic.

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