Abstract
BACKGROUND: Non-diabetic hypoglycemia presents a substantial diagnostic challenge due to its diverse and often nonspecific symptomatology. The resultant delay in diagnosis can lead to a myriad of misdiagnoses. This misidentification not only prolongs patient suffering but also elevates the risk of severe complications, such as permanent neurologic damage and mortality. Recognizing the clinical nuances of non-diabetic hypoglycemia is paramount for timely and accurate diagnosis, which ultimately enhances patient outcomes and safety. MAIN BODY: A position statement has been formulated by the Arabic Association for the Study of Diabetes and Metabolism (AASD) to address the complexities of diagnosing non-diabetic hypoglycemia. This statement highlights the challenges and pitfalls, covering key areas such as the vast spectrum of non-diabetic hypoglycemia within underreported subspecialties. It aims to elucidate the critical need for heightened clinical awareness and multidisciplinary management approaches to mitigate the profound impacts on patient health. Additionally, the statement provides guidance for overcoming barriers to optimal care. The team has distilled their experience into clinical algorithms to simplify information for healthcare professionals. CONCLUSION: Non-diabetic hypoglycemia is a rare condition that requires a comprehensive approach, including detailed history, medication review, and physical examination. Common pitfalls in diagnosis and management should be understood to avoid unnecessary evaluation and costs while avoiding misdiagnosis of patients with treatable or serious disorders.