Sequential Amiodarone-Induced Thyroid Dysfunction: From Myxedema Coma to Late-Onset Type 1 Thyrotoxicosis After Drug Withdrawal

Our report underscores three key points: (1) the prolonged metabolic effects of iodine load and tissue toxicity even after amiodarone cessation, (2) the possibility of reversible amiodarone-induced hypothyroidism preceding subsequent thyrotoxicosis, and (3) the need for long-term thyroid function monitoring, even after amiodarone withdrawal.