Increased microRNA-146a levels in plasma of patients with newly diagnosed type 2 diabetes mellitus

新诊断 2 型糖尿病患者血浆中 microRNA-146a 水平升高

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作者:Ying Rong, Wei Bao, Zhilei Shan, Jun Liu, Xuefeng Yu, Songfan Xia, Hui Gao, Xia Wang, Ping Yao, Frank B Hu, Liegang Liu

Background

MicroRNAs (miRNAs), a class of small non-coding RNAs, are thought to serve as crucial regulators of gene expression. Dysregulated expression of miRNAs has been described in various diseases and may contribute to related pathologic processes. Our

Significance

We found that circulating miRNA-146a levels were significantly elevated in new-T2DM patients compared with healthy controls. Whether expression of circulating miRNA-146a holds predictive value for T2DM warrants further investigations.

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