Character-level linguistic biomarkers for precision assessment of cognitive decline: a symbolic recurrence approach

基于字符级语言生物标志物的认知衰退精准评估:一种符号递归方法

阅读:1

Abstract

Early-stage Alzheimer's disease (AD) remains difficult to assess using conventional linguistic or cognitive assessments, which often overlook subtle and individualized disruptions in speech. In this work, we propose a novel biomarker discovery framework that leverages fine-grained, character-level information from speech transcripts to capture these early cognitive changes. By encoding transcripts symbolically at the character level and applying recurrence quantification analysis (RQA), we generate interpretable recurrence plots that reveal temporal dynamics in speech patterns such as pauses, repetitions, and hesitations. Siamese neural networks are then used to learn embeddings from these recurrence representations, enabling the discovery of discriminative linguistic biomarkers associated with cognitive decline. Applied to the DementiaBank corpus, our approach uncovers meaningful character-level signatures and enables visualization of subtle cognitive disruptions through recurrence plots. These findings suggest that character-level temporal patterns may offer a promising new direction for digital biomarker discovery in dementia research, complementing traditional word-level analyses and enhancing interpretability for clinical applications.

特别声明

1、本页面内容包含部分的内容是基于公开信息的合理引用;引用内容仅为补充信息,不代表本站立场。

2、若认为本页面引用内容涉及侵权,请及时与本站联系,我们将第一时间处理。

3、其他媒体/个人如需使用本页面原创内容,需注明“来源:[生知库]”并获得授权;使用引用内容的,需自行联系原作者获得许可。

4、投稿及合作请联系:info@biocloudy.com。