Unexpected Long-Term Disease Control in Lung Cancer With Sacral Metastases After Conventional Radiotherapy and Chemotherapy Despite Discontinuation of Maintenance Therapy: A Case Report

一例接受常规放疗和化疗后,尽管停止维持治疗,但伴有骶骨转移的肺癌患者仍意外获得长期疾病控制:病例报告

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Abstract

Novel treatments, including stereotactic body radiotherapy (SBRT), targeted therapies, and immune checkpoint inhibitors (ICIs), have improved the prognosis and outcomes of patients with metastatic lung cancer. However, not all patients are eligible for these treatments; furthermore, these novel therapies are not readily available in developing countries. We report a 54-year-old man who presented with a sacral mass, initially suspected as a chordoma and underwent subtotal resection. Further evaluation revealed a mass in the lung, confirming the pulmonary origin of the tumor. He received palliative radiotherapy (RT) to the residual sacral lesion, chemotherapy with bevacizumab, and 3D-RT to a lung lesion. Bevacizumab was discontinued after one year of maintenance therapy following a serious gastrointestinal perforation. Surprisingly, two years after stopping all treatment, he has had no sign of disease progression.

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