Abstract
BACKGROUND: Precise delineation of gross tumor volume (GTV) is fundamental for effective radiation therapy in low-grade skull base meningiomas. Magnetic resonance imaging (MRI) serves as the primary imaging tool but may not fully represent tumor extent. This study investigates the additional value of incorporating Somatostatin receptor (SSTR)-directed PET/CT in radiation therapy planning. METHODS: A retrospective analysis was conducted with four experienced radiation oncologists contouring GTVs for skull base meningiomas using MRI alone (GTV_MRI), PET/CT alone (GTV_PET/CT), and both modalities combined (GTV_ALL). Consensus ground truth volumes were generated for each modality through a STAPLE algorithm. Agreement between modalities, excluding observer variability, was assessed using statistical metrics including Dice Similarity Coefficient (DSC), Jaccard Index (JCI), Hausdorff distance (HD95), Geographical Miss Index (GMI), sensitivity, and kappa statistics. RESULTS: The study included 25 patients (15 females, 10 males; median age 56 years (range: 23-74 years), with 96% achieving local control post-radiotherapy over a median follow-up of 64 months (range: 28-135 months). Substantial interobserver agreement was observed, with median kappa values of 0.74 for GTV_MRI, 0.68 for GTV_PET/CT, and 0.77 for GTV_ALL. Median consensus volumes were 6.65 cc (MRI(STAPLE)), 7.21 cc (PET(STAPLE)), and 6.73 cc (ALL(STAPLE)). The median GMI for MRI(STAPLE) compared to ALL(STAPLE) was 0.18 (IQR: 0.11-0.39), and 0.21 (IQR: 0.15-0.28) for PET(STAPLE) compared to ALL(STAPLE). The DSC indicated the lowest concordance between MRI(STAPLE) and PET(STAPLE) with a median of 0.75 (IQR: 0.59-0.82), followed by PET(STAPLE) versus ALL(STAPLE) with a median DSC of 0.84 (IQR: 0.79-0.89), and MRI(STAPLE) versus ALL(STAPLE) with a median DSC of 0.89 (IQR: 0.76-0.92). The integration of PET/CT with MRI significantly enhanced concordance metrics. CONCLUSION: Combining MRI and PET/CT improves GTV delineation in low-grade skull base meningiomas, as PET/CT can reveal regions missed by MRI, which may slightly underestimate tumor size. This multimodal imaging approach enhances consensus and supports its role in radiotherapy planning. Standardized protocols and technical integration remain key future goals.