Abstract
BACKGROUND: The association between cumulative live birth rate (CLBR) and oocyte aspiration in the context of maternal age is not well understood in the Indian population. AIMS: To find the relationship between CLBR and a single oocyte aspiration. SETTINGS AND DESIGN: This is a retrospective study analysing the data of 1989 women who underwent in vitro fertilisation (IVF) between January 2015 and December 2019, at Gunasheela Surgical and Maternity Hospital, India. MATERIALS AND METHODS: Participants were divided into two groups based on age: ≤35 (group I, n = 1665) and >35 (Group II, n = 324). CLBR per single oocyte aspiration in fresh and subsequent three frozen embryo transfer cycles was estimated. STATISTICAL ANALYSIS USED: Logistic regression analysis was used to show the likelihood of pregnancy rate, and CLBR per aspiration after treatment was represented as odd's ratios (OR) with 95% confidence intervals. RESULTS: Maximal CLBR for Groups I and II was 81.25% with >25 oocytes and 75% with 16-20 oocytes, respectively. In the fresh ET cycle, maximal pregnancy and live birth rates were observed in 6-10 oocytes for Group I (54% and 41%) and in 16-20 oocytes for Group II (75% and 75%). The ORs for pregnancy rate (P = 0.01) and CLBR (P = 0.007) increased with an increase in the number of oocytes retrieved. The ORs for pregnancy rate and CLBR for Group II were 0.68 (P = 0.002) and 0.58 (P = 0.00002), respectively as compared to Group I. Optimal oocytes required to achieve positive IVF outcomes in fresh/frozen ET cycles were low in Group I (6-10 oocytes), but higher in Group II (16-20 oocytes). CONCLUSION: Robust positive relationship was observed between the number of oocytes retrieved and CLBR in women of both age groups.