American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models

美国甲状腺协会在啮齿动物和细胞模型中研究甲状腺激素经济性和作用的指南

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作者:Antonio C Bianco, Grant Anderson, Douglas Forrest, Valerie Anne Galton, Balázs Gereben, Brian W Kim, Peter A Kopp, Xiao Hui Liao, Maria Jesus Obregon, Robin P Peeters, Samuel Refetoff, David S Sharlin, Warner S Simonides, Roy E Weiss, Graham R Williams; American Thyroid Association Task Force on App

Background

An in-depth understanding of the fundamental principles that regulate thyroid hormone homeostasis is critical for the development of new diagnostic and treatment approaches for patients with thyroid disease. Summary: Important clinical practices in use today for the treatment of patients with hypothyroidism, hyperthyroidism, or thyroid cancer are the result of laboratory discoveries made by scientists investigating the most basic aspects of thyroid structure and molecular biology. In this document, a panel of experts commissioned by the American Thyroid Association makes a series of recommendations related to the study of thyroid hormone economy and action. These recommendations are intended to promote standardization of study design, which should in turn increase the comparability and reproducibility of experimental findings. Conclusions: It is expected that adherence to these recommendations by investigators in the field will facilitate progress towards a better understanding of the thyroid gland and thyroid hormone dependent processes.

Conclusions

It is expected that adherence to these recommendations by investigators in the field will facilitate progress towards a better understanding of the thyroid gland and thyroid hormone dependent processes.

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