Abstract
BACKGROUND: As climate change intensifies, ambient temperatures have become a global concern, leading to an increasing number of studies examining the impact of temperature on human health. Extreme weather events, including heatwaves and cold spells, are becoming more frequent and severe. Numerous studies have highlighted the positive correlation between non-optimal ambient temperatures and mortality. Understanding these impacts is crucial for developing targeted public health interventions and accurately predicting the future health burden associated with climate variability. This study aims to estimate the relative risks and mortality burden associated with temperature extremes over the past decade, focusing on the contributions of both heat and cold, as well as mild and extreme temperatures, and identifying vulnerable populations. By doing so, filling a regional research gap in Guiyang. METHODS: We collected the daily weather and mortality data from 2013 to 2023. Descriptive analysis was conducted to characterize overall weather patterns and mortality trends during the study period. A quasi-Poisson regression with a distributed lag non-linear model (DLNM), incorporating a 21-day lag and controlling for trends, air pollutants, and the day of the week, was applied to estimate the cumulative relative risks of non-accidental mortality due to non-optimal and extreme temperatures. We calculated attributable fractions and attributable numbers for heat and cold (defined as temperatures above and below the daily mean temperature), mild temperatures (defined using cutoffs at the minimum mortality temperature, with mild heat ranging from the minimum mortality temperature to the 97.5th temperature percentile and mild cold ranging from the 2.5th temperature percentile to the minimum mortality temperature) and extreme temperatures (defined as temperatures below the 2.5th temperature percentile for extreme cold and above the 97.5th temperature percentile for extreme heat). RESULTS: A total of 140,099 non-accidental deaths were included in the study.Temperature and mortality showed U-shaped associations, except for 0-64 years age group. For extreme low temperatures, the effects appeared in lag 2 to 4 days and lasted for approximately 18 days, peaking on lag day 5, yielding a cumulative relative risks (RRs) of 1.24% (95% CI 1.14% to 1.36%) for non-accidental mortality. For extreme high temperatures, the strongest effect was observed on the same day, with an RR of 1.18%(95% CI 1.03% to 1.35%). The attributable fraction of non-accidental mortality associated with non-optimal temperatures was 9.21% (95% eCI: 5.32% to 12.15%). The mortality burden from heat and cold was 5.55% (95% eCI: 2.04% to 8.59%) and 3.67% (95% eCI: 1.45% to 5.80%), respectively. Mild heat was responsible for the majority of the mortality burden. CONCLUSION: Extreme low temperatures had higher cumulative relative risk and a prolonged effect compared to extreme high temperatures. The attributable fraction associated with non-optimal temperatures was highest for respiratory-related deaths. Mild heat was responsible for the majority of the mortality burden. Additionally, males and the individuals aged 65 years and above were particularly vulnerable populations.