Preconditioning with triiodothyronine improves the clinical signs and acute tubular necrosis induced by ischemia/reperfusion in rats
三碘甲状腺原氨酸预处理可改善大鼠缺血/再灌注引起的临床症状和急性肾小管坏死
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作者：Carla Ferreyra, Félix Vargas, Isabel Rodríguez-Gómez, Rocío Pérez-Abud, Francisco O'Valle, Antonio Osuna
| 期刊： | PLoS One | 影响因子： | 2.900 |
| 时间： | 2013 | 起止号： | 2013 Sep 26;8(9):e74960. |
| doi： | 10.1371/journal.pone.0074960 | 方法学： | FCM、IF、IHC-P、WB |
| 靶点： | PTPRC | 研究方向： | 信号转导 |
Background
Renal ischemia/reperfusion (I/R) injury is manifested by acute renal failure (ARF) and acute tubular necrosis (ATN). The
Conclusions
This study demonstrates that preconditioning rats with a single dose of T3 improves the clinical signs and ATN of renal I/R injury. These beneficial effects are accompanied by reductions in oxidative stress, inflammation, and renal PARP-1 expression, indicating that this sequence of factors plays an important role in the ATN induced by I/R injury.
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