Abstract
The recent trend away from ANOVA-based analyses places experimental investigations into the neurobiology of cognition in more naturalistic and ecologically valid designs within reach. Using mixed-effects models for epoch-based regression, we demonstrate the feasibility of examining event-related potentials (ERPs), and in particular the N400, to study the neural dynamics of human auditory language processing in a naturalistic setting. Despite the large variability between trials during naturalistic stimulation, we replicated previous findings from the literature: the effects of frequency, animacy, and word order and find previously unexplored interaction effects. This suggests a new perspective on ERPs, namely, as a continuous modulation reflecting continuous stimulation instead of a series of discrete and essentially sequential processes locked to discrete events.