Background
Dimethyl fumarate is an oral treatment for multiple sclerosis, whose mechanism of action is not fully understood.
Conclusion
This study investigates the effect of dimethyl fumarate on DNA methylation in multiple sclerosis patients.
Methods
We performed Illumina EPIC arrays to investigate the DNA methylation profiles of CD4+ T cells derived from multiple sclerosis patients before and after dimethyl fumarate treatment.
Objective
To investigate the effects of dimethyl fumarate on DNA methylation in the CD4+ T cells of multiple sclerosis patients.
Results
Treatment with dimethyl fumarate resulted in 97% of differentially methylated positions showing hypermethylation. Four genes, SNORD1A, SHTN1, MZB1 and TNF had a differentially methylated region located within the transcriptional start site.