Abstract
BACKGROUND: Gastric mucosa-associated lymphoid tissue (MALT) lymphoma presents with various clinical presentations and endoscopic features. While gastric lesions are primarily assessed via endoscopic forceps biopsy, pathological confirmation of MALT lymphoma is frequently challenging, with low detection rates commonly observed. CASE SUMMARY: We describe a 61-year-old male patient with gastric MALT lymphoma due to intermittent abdominal discomfort lasting over six months. The initial endoscopic forceps biopsy was suggestive of gastric lymphoma. Confirmation of the MALT lymphoma diagnosis was ultimately obtained through a jumbo biopsy specimen harvested via endoscopic submucosal dissection (ESD). CONCLUSION: We report a case of gastric MALT lymphoma diagnosed through ESD, highlighting its potential as a diagnostic tool when forceps biopsy yields negative or inconclusive results.