Abstract
BACKGROUND: Coexisting primary hematologic malignancies in untreated multiple myeloma (MM) are rare. CASE: A 69-year-old man with smoldering multiple myeloma (sMM) presented with lymphadenopathies and an intracranial mass. He was diagnosed with diffuse large B-cell lymphoma (DLBCL), classic Hodgkin lymphoma (cHL), and sMM. The patient received R-CHOP and R-ICE, followed by autologous stem cell transplantation, achieving complete remission of DLBCL and cHL, and very good partial remission of MM. CONCLUSION: This case illustrates the complexity of managing multiple malignancies and the importance of a tailored therapeutic approach.