Abstract
RATIONALE: Adenosquamous carcinoma of the scrotum is a rare cancer associated with poor prognosis. It is diagnosed through the presence of both adenocarcinoma and squamous cell carcinoma. PATIENT CONCERNS: It may be difficult to diagnose at early stages and may have poor survival. DIAGNOSES: We report a case of adenosquamous carcinoma of the scrotum in a 58-year-old male patient who presented with left scrotal mass for >1 year. INTERVENTIONS: This is the first case in the literature of primary adenosquamous carcinoma of the scrotum managed successfully with surgery and post-surgery chemotherapy and radiotherapy. OUTCOMES: The patient remained disease-free for 10 months postoperatively. LESSONS: The surgery treatment combined with postoperative radiotherapy and chemotherapy can improve the survival of adenosquamous carcinoma.