Generation of a human induced pluripotent stem cell line (INNDSUi003-A) derived from patient with Becker muscular dystrophy (BMD)

源自贝克尔型肌营养不良症 (BMD) 患者的人类诱导性多能干细胞系 (INNDSUi003-A) 的生成

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作者:Xinbo Ji, Yu Wang, Ping Sun, Dongdong Wang, Xiaohan Sun, Rui Zhang, Jingwen Xu, Wei Li, Fuchen Liu, Chuanzhu Yan

Abstract

Becker muscular dystrophy (BMD), an X-linked recessive disorder caused of mutation in the dystrophin gene, is characterized by progressive muscle degeneration and proximal muscle weakness. We generated a human induced pluripotent stem cell (hiPSC) line from the fibroblasts isolated from patient with BMD by non-integrating reprogramming methods. The iPSC line highly expresses pluripotency markers, displays the normal karyotype and is able to differentiate into the three germ layers in vitro. The iPSC line will be a useful tool to study the pathogenesis of BMD and for drug screening.

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